Pub. Date : 2010 May 14
PMID : 20138958
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Iodine induces apoptosis via regulating MAPKs-related p53, p21, and Bcl-xL in thyroid cancer cells. | Iodine | tumor protein p53 | Homo sapiens |
| 2 | Iodine treatment decreased the level of mutant p53 including the R273H mutant that possesses anti-apoptotic features, but increased the p21 level. | Iodine | tumor protein p53 | Homo sapiens |
| 3 | Moreover, iodine transiently activated the subfamily members of mitogen activated protein kinases (MAPKs) (ERK1/2, p38 and JNK1/2) which contribute to modulate p53, p21 and Bcl-xL expression. | Iodine | tumor protein p53 | Homo sapiens |
| 4 | Collectively, iodine-induced apoptotic pathway is involved in the activation of MAPKs-related p21, Bcl-xL and mutant p53 regulation. | Iodine | tumor protein p53 | Homo sapiens |