Title : T cell receptor-dependent regulation of lipid rafts controls naive CD8+ T cell homeostasis.

Pub. Date : 2010 Feb 26

PMID : 20137986






2 Functional Relationships(s)
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1 Hypersensitivity of CD8(+) T cells to IL-2 was dependent on a low-level TCR signal, associated with high expression of CD5 and GM1, a marker for lipid rafts, and was abolished by disruption of lipid rafts. G(M1) Ganglioside T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens
2 Thus, TCR contact with antigen upregulates GM1 and amplifies responsiveness of naive CD8(+) T cells to IL-2, thereby making the cells highly sensitive to exogenous IL-2 from CD4(+) T helper cells. G(M1) Ganglioside T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens