Pub. Date : 2010 Feb 26
PMID : 20137986
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hypersensitivity of CD8(+) T cells to IL-2 was dependent on a low-level TCR signal, associated with high expression of CD5 and GM1, a marker for lipid rafts, and was abolished by disruption of lipid rafts. | G(M1) Ganglioside | T cell receptor beta variable 20/OR9-2 (non-functional) | Homo sapiens |
| 2 | Thus, TCR contact with antigen upregulates GM1 and amplifies responsiveness of naive CD8(+) T cells to IL-2, thereby making the cells highly sensitive to exogenous IL-2 from CD4(+) T helper cells. | G(M1) Ganglioside | T cell receptor beta variable 20/OR9-2 (non-functional) | Homo sapiens |