Title : TNF-alpha-induced mitochondrial alterations in human T cells requires FADD and caspase-8 activation but not RIP and caspase-3 activation.

Pub. Date : 2010 Sep 15

PMID : 20136500






1 Functional Relationships(s)
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1 Since pan-caspase inhibitor z-VAD-fmk abolished the TNF-alpha-induced mitochondrial changes, z-DEVD-fmk, an inhibitor of caspase-3 had no effect, suggesting that TNF-alpha-induced mitochondrial changes or cytochrome c and Smac release requires caspase-8 but not caspase-3 activation. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone caspase 8 Homo sapiens