Title : Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells.

Pub. Date : 2010 Aug

PMID : 20135346






1 Functional Relationships(s)
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1 As mTOR inhibition by rapamycin is associated with attenuation of negative feedback to IRS-1, rapamycin is known to increase activation of AKT, which may reduce its anti-neoplastic activity. Sirolimus insulin receptor substrate 1 Homo sapiens