Pub. Date : 2010 May
PMID : 20132841
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CsA inhibits isomerase activity of cellular-encoded cyclophilin proteins, of which cyclophilin A (CypA) in particular is required for HCV replication. | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |
| 2 | Importantly, the NS5A-CypA interactions were sensitive to CsA in a dose-responsive manner and an isomerase mutant of CypA interacted with NS5A less efficiently than wild-type CypA. | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |
| 3 | Importantly, the NS5A-CypA interactions were sensitive to CsA in a dose-responsive manner and an isomerase mutant of CypA interacted with NS5A less efficiently than wild-type CypA. | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |
| 4 | Importantly, the NS5A-CypA interactions were sensitive to CsA in a dose-responsive manner and an isomerase mutant of CypA interacted with NS5A less efficiently than wild-type CypA. | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |
| 5 | These findings correlate the anti-HCV properties of CsA with an ability of the compound to disrupt NS5A-CypA interactions in vitro and in vivo, whilst providing the basis for development of assay platforms suitable to screen compound libraries for novel inhibitors of the NS5A-CypA interaction. | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |
| 6 | These findings correlate the anti-HCV properties of CsA with an ability of the compound to disrupt NS5A-CypA interactions in vitro and in vivo, whilst providing the basis for development of assay platforms suitable to screen compound libraries for novel inhibitors of the NS5A-CypA interaction. | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |