Title : Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation.

Pub. Date : 2010 Feb 4

PMID : 20132554






3 Functional Relationships(s)
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1 Demethylation agent 5-aza-2"-deoxycytidine (5-aza-dc) selectively inhibits DNA methyltransferases, DNMT3a and DNMT3b, and restored CASP8 and maspin gene expression in breast cancer cells. Decitabine caspase 8 Homo sapiens
2 Demethylation agent 5-aza-2"-deoxycytidine (5-aza-dc) selectively inhibits DNA methyltransferases, DNMT3a and DNMT3b, and restored CASP8 and maspin gene expression in breast cancer cells. Decitabine caspase 8 Homo sapiens
3 5-aza-dc also reduced histone H3k9me2 occupancy on CASP8 promoter in SKBR3cells, but not in MCF-7 cells. Decitabine caspase 8 Homo sapiens