Pub. Date : 2010 May
PMID : 20132464
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Behavioral investigations of selective and potent metabotropic glutamate receptor type 5 (mGluR5) antagonists in animal models suggest involvement of mGluR5 in compensatory mechanisms of the basal ganglia circuitry in Parkinson"s disease and levodopa (L-Dopa) induced motor complications. | Levodopa | glutamate receptor, ionotropic, kainate 1 | Mus musculus |
| 2 | Behavioral investigations of selective and potent metabotropic glutamate receptor type 5 (mGluR5) antagonists in animal models suggest involvement of mGluR5 in compensatory mechanisms of the basal ganglia circuitry in Parkinson"s disease and levodopa (L-Dopa) induced motor complications. | Levodopa | glutamate receptor, ionotropic, kainate 1 | Mus musculus |
| 3 | Behavioral investigations of selective and potent metabotropic glutamate receptor type 5 (mGluR5) antagonists in animal models suggest involvement of mGluR5 in compensatory mechanisms of the basal ganglia circuitry in Parkinson"s disease and levodopa (L-Dopa) induced motor complications. | Levodopa | glutamate receptor, ionotropic, kainate 1 | Mus musculus |
| 4 | The effect of a chronic 1 month treatment with L-Dopa on mGluR5-specific binding and mRNA levels was investigated in MPTP monkeys killed 4 or 24 h after their last L-Dopa administration. | Levodopa | glutamate receptor, ionotropic, kainate 1 | Mus musculus |
| 5 | In contrast, caudate nucleus and putamen mGluR5 mRNA levels were elevated only in L-Dopa-treated MPTP monkeys killed 4 h after their last L-Dopa administration. | Levodopa | glutamate receptor, ionotropic, kainate 1 | Mus musculus |
| 6 | In contrast, caudate nucleus and putamen mGluR5 mRNA levels were elevated only in L-Dopa-treated MPTP monkeys killed 4 h after their last L-Dopa administration. | Levodopa | glutamate receptor, ionotropic, kainate 1 | Mus musculus |
| 7 | MPTP monkeys killed 4 h after their last L-Dopa treatment showed higher caudate nucleus and putamen L-Dopa concentrations compared with those killed after 24 h. Hence, mGluR5 in the putamen are sensitive to presence of L-Dopa leading to a rapid decrease of [(3)H]ABP688-specific binding possibly involving a direct mGluR5/dopamine receptors interaction. | Levodopa | glutamate receptor, ionotropic, kainate 1 | Mus musculus |
| 8 | MPTP monkeys killed 4 h after their last L-Dopa treatment showed higher caudate nucleus and putamen L-Dopa concentrations compared with those killed after 24 h. Hence, mGluR5 in the putamen are sensitive to presence of L-Dopa leading to a rapid decrease of [(3)H]ABP688-specific binding possibly involving a direct mGluR5/dopamine receptors interaction. | Levodopa | glutamate receptor, ionotropic, kainate 1 | Mus musculus |
| 9 | MPTP monkeys killed 4 h after their last L-Dopa treatment showed higher caudate nucleus and putamen L-Dopa concentrations compared with those killed after 24 h. Hence, mGluR5 in the putamen are sensitive to presence of L-Dopa leading to a rapid decrease of [(3)H]ABP688-specific binding possibly involving a direct mGluR5/dopamine receptors interaction. | Levodopa | glutamate receptor, ionotropic, kainate 1 | Mus musculus |