Title : Effect of L-Dopa on metabotropic glutamate receptor 5 in the brain of parkinsonian monkeys.

Pub. Date : 2010 May

PMID : 20132464






9 Functional Relationships(s)
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1 Behavioral investigations of selective and potent metabotropic glutamate receptor type 5 (mGluR5) antagonists in animal models suggest involvement of mGluR5 in compensatory mechanisms of the basal ganglia circuitry in Parkinson"s disease and levodopa (L-Dopa) induced motor complications. Levodopa glutamate receptor, ionotropic, kainate 1 Mus musculus
2 Behavioral investigations of selective and potent metabotropic glutamate receptor type 5 (mGluR5) antagonists in animal models suggest involvement of mGluR5 in compensatory mechanisms of the basal ganglia circuitry in Parkinson"s disease and levodopa (L-Dopa) induced motor complications. Levodopa glutamate receptor, ionotropic, kainate 1 Mus musculus
3 Behavioral investigations of selective and potent metabotropic glutamate receptor type 5 (mGluR5) antagonists in animal models suggest involvement of mGluR5 in compensatory mechanisms of the basal ganglia circuitry in Parkinson"s disease and levodopa (L-Dopa) induced motor complications. Levodopa glutamate receptor, ionotropic, kainate 1 Mus musculus
4 The effect of a chronic 1 month treatment with L-Dopa on mGluR5-specific binding and mRNA levels was investigated in MPTP monkeys killed 4 or 24 h after their last L-Dopa administration. Levodopa glutamate receptor, ionotropic, kainate 1 Mus musculus
5 In contrast, caudate nucleus and putamen mGluR5 mRNA levels were elevated only in L-Dopa-treated MPTP monkeys killed 4 h after their last L-Dopa administration. Levodopa glutamate receptor, ionotropic, kainate 1 Mus musculus
6 In contrast, caudate nucleus and putamen mGluR5 mRNA levels were elevated only in L-Dopa-treated MPTP monkeys killed 4 h after their last L-Dopa administration. Levodopa glutamate receptor, ionotropic, kainate 1 Mus musculus
7 MPTP monkeys killed 4 h after their last L-Dopa treatment showed higher caudate nucleus and putamen L-Dopa concentrations compared with those killed after 24 h. Hence, mGluR5 in the putamen are sensitive to presence of L-Dopa leading to a rapid decrease of [(3)H]ABP688-specific binding possibly involving a direct mGluR5/dopamine receptors interaction. Levodopa glutamate receptor, ionotropic, kainate 1 Mus musculus
8 MPTP monkeys killed 4 h after their last L-Dopa treatment showed higher caudate nucleus and putamen L-Dopa concentrations compared with those killed after 24 h. Hence, mGluR5 in the putamen are sensitive to presence of L-Dopa leading to a rapid decrease of [(3)H]ABP688-specific binding possibly involving a direct mGluR5/dopamine receptors interaction. Levodopa glutamate receptor, ionotropic, kainate 1 Mus musculus
9 MPTP monkeys killed 4 h after their last L-Dopa treatment showed higher caudate nucleus and putamen L-Dopa concentrations compared with those killed after 24 h. Hence, mGluR5 in the putamen are sensitive to presence of L-Dopa leading to a rapid decrease of [(3)H]ABP688-specific binding possibly involving a direct mGluR5/dopamine receptors interaction. Levodopa glutamate receptor, ionotropic, kainate 1 Mus musculus