Pub. Date : 2010 Mar
PMID : 20128802
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | KEY RESULTS: In oxaliplatin-treated CHK2 KO cells, accelerated apoptosis was accompanied by attenuated p53 stabilization and p21(WAF-1) up-regulation correlating with increased Bax expression, cytochrome c release and elevated caspase activity. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 2 | This "uncoupling" of p53 stabilization and Bax up-regulation in CHK2 KO cells suggested oxaliplatin-induced apoptosis was due to a p53-independent response. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 3 | This "uncoupling" of p53 stabilization and Bax up-regulation in CHK2 KO cells suggested oxaliplatin-induced apoptosis was due to a p53-independent response. | Oxaliplatin | tumor protein p53 | Homo sapiens |