Title : Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells.

Pub. Date : 2010 Feb

PMID : 20128797






4 Functional Relationships(s)
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1 KEY RESULTS: Exposure to high glucose concentrations strongly inhibited eNOS phosphorylation at Ser-1177 and dephosphorylation at Thr-495 in bradykinin (BK)-stimulated cells. Glucose kininogen 1 Homo sapiens
2 KEY RESULTS: Exposure to high glucose concentrations strongly inhibited eNOS phosphorylation at Ser-1177 and dephosphorylation at Thr-495 in bradykinin (BK)-stimulated cells. Glucose kininogen 1 Homo sapiens
3 The effect of oligonol on BK dephosphorylation under high glucose was mimicked by protein kinase C (PKC) epsilon-neutralizing peptides. Glucose kininogen 1 Homo sapiens
4 Oligonol also prevented high glucose-induced attenuation of BK-stimulated NO production. Glucose kininogen 1 Homo sapiens