Pub. Date : 2010 Mar
PMID : 20126979
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PSK enhances the efficacy of docetaxel in human gastric cancer cells through inhibition of nuclear factor-kappaB activation and survivin expression. | Docetaxel | baculoviral IAP repeat-containing 5 | Mus musculus |
| 2 | In addition, to elucidate the molecular mechanism, we analyzed the activation of NF-kappaB and the subsequent production of the antiapoptotic molecule survivin in combined treatment with docetaxel and PSK. | Docetaxel | baculoviral IAP repeat-containing 5 | Mus musculus |
| 3 | In SCID mouse, PSK significantly inhibited growth of TMK-1 subcutaneous xenografts in combination with low-dose docetaxel, and decreased the docetaxel-induced survivin expression in TMK-1 xenografts. | Docetaxel | baculoviral IAP repeat-containing 5 | Mus musculus |
| 4 | Our data suggest that PSK enhanced the efficacy of docetaxel against human gastric cancer both in vitro and in vivo, at least in part, by downregulating NF-kappaB activation and survivin expression induced by low-dose docetaxel. | Docetaxel | baculoviral IAP repeat-containing 5 | Mus musculus |
| 5 | Our data suggest that PSK enhanced the efficacy of docetaxel against human gastric cancer both in vitro and in vivo, at least in part, by downregulating NF-kappaB activation and survivin expression induced by low-dose docetaxel. | Docetaxel | baculoviral IAP repeat-containing 5 | Mus musculus |