Title : Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.

Pub. Date : 2010 Feb

PMID : 20124700






1 Functional Relationships(s)
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1 The Y224D mutation of AKR1C21 reduced the K(m) value for NADP(H) by up to 80-fold and completely reversed the 17alpha stereospecificity of the enzyme. NADP aldo-keto reductase family 1, member C21 Mus musculus