Pub. Date : 2010 Mar
PMID : 20121949
19 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study investigated the detailed mechanisms by which Snail upregulates gene expression of the CDK inhibitor p15(INK4b) in HepG2 induced by the tumor promoter tetradecanoyl phorbol acetate (TPA). | Tetradecanoylphorbol Acetate | snail family transcriptional repressor 1 | Homo sapiens |
| 2 | This study investigated the detailed mechanisms by which Snail upregulates gene expression of the CDK inhibitor p15(INK4b) in HepG2 induced by the tumor promoter tetradecanoyl phorbol acetate (TPA). | Tetradecanoylphorbol Acetate | snail family transcriptional repressor 1 | Homo sapiens |
| 3 | Gene expression of EGR-1, Snail and SP-1 can be induced by TPA within 0.5-6 h. In addition, basal levels of SP-1, but not of the other two transcriptional factors, were observed. | Tetradecanoylphorbol Acetate | snail family transcriptional repressor 1 | Homo sapiens |
| 4 | Blockade of TPA-induced gene expression of Snail, EGR-1 or SP-1 suppressed activation of the p15-pro228 reporter plasmid harboring the TPA-responsive element. | Tetradecanoylphorbol Acetate | snail family transcriptional repressor 1 | Homo sapiens |
| 5 | Blockade of TPA-induced gene expression of Snail, EGR-1 or SP-1 suppressed activation of the p15-pro228 reporter plasmid harboring the TPA-responsive element. | Tetradecanoylphorbol Acetate | snail family transcriptional repressor 1 | Homo sapiens |
| 6 | In an EMSA, a DNA-protein complex was elevated by TPA, which can be blocked by antibodies against EGR-1, SP-1 or Snail at 6 h. Immunoprecipitation/western blotting demonstrated that TPA could trigger the association of EGR-1 with Snail or SP-1. | Tetradecanoylphorbol Acetate | snail family transcriptional repressor 1 | Homo sapiens |
| 7 | In an EMSA, a DNA-protein complex was elevated by TPA, which can be blocked by antibodies against EGR-1, SP-1 or Snail at 6 h. Immunoprecipitation/western blotting demonstrated that TPA could trigger the association of EGR-1 with Snail or SP-1. | Tetradecanoylphorbol Acetate | snail family transcriptional repressor 1 | Homo sapiens |
| 8 | In an EMSA, a DNA-protein complex was elevated by TPA, which can be blocked by antibodies against EGR-1, SP-1 or Snail at 6 h. Immunoprecipitation/western blotting demonstrated that TPA could trigger the association of EGR-1 with Snail or SP-1. | Tetradecanoylphorbol Acetate | snail family transcriptional repressor 1 | Homo sapiens |
| 9 | In an EMSA, a DNA-protein complex was elevated by TPA, which can be blocked by antibodies against EGR-1, SP-1 or Snail at 6 h. Immunoprecipitation/western blotting demonstrated that TPA could trigger the association of EGR-1 with Snail or SP-1. | Tetradecanoylphorbol Acetate | snail family transcriptional repressor 1 | Homo sapiens |
| 10 | Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation. | Tetradecanoylphorbol Acetate | snail family transcriptional repressor 1 | Homo sapiens |
| 11 | Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation. | Tetradecanoylphorbol Acetate | snail family transcriptional repressor 1 | Homo sapiens |
| 12 | Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation. | Tetradecanoylphorbol Acetate | snail family transcriptional repressor 1 | Homo sapiens |
| 13 | Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation. | Tetradecanoylphorbol Acetate | snail family transcriptional repressor 1 | Homo sapiens |
| 14 | Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation. | Tetradecanoylphorbol Acetate | snail family transcriptional repressor 1 | Homo sapiens |
| 15 | Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation. | Tetradecanoylphorbol Acetate | snail family transcriptional repressor 1 | Homo sapiens |
| 16 | Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation. | Tetradecanoylphorbol Acetate | snail family transcriptional repressor 1 | Homo sapiens |
| 17 | Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation. | Tetradecanoylphorbol Acetate | snail family transcriptional repressor 1 | Homo sapiens |
| 18 | Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation. | Tetradecanoylphorbol Acetate | snail family transcriptional repressor 1 | Homo sapiens |
| 19 | In conclusion, Snail associates with EGR-1 and SP-1 to mediate TPA-induced transcriptional upregulation of p15(INK4b) in HepG2. | Tetradecanoylphorbol Acetate | snail family transcriptional repressor 1 | Homo sapiens |