Title : A Korean family of familial medullary thyroid cancer with Cys618Ser RET germline mutation.

Pub. Date : 2010 Feb

PMID : 20119574






6 Functional Relationships(s)
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1 The majority of germline mutations in FMTC have been found in exons 10 and 11 of the RET proto-oncogene, specifically within the cysteine codons 609, 611, 618, 620, and 634. Cysteine ret proto-oncogene Homo sapiens
2 We report a RET mutation in exon10, codon 618 that causes substitution of a cysteine by a serine in the cysteine-rich domain of the RET receptor in a three-generation FMTC family composed of 30 members with 11 carriers. Cysteine ret proto-oncogene Homo sapiens
3 We report a RET mutation in exon10, codon 618 that causes substitution of a cysteine by a serine in the cysteine-rich domain of the RET receptor in a three-generation FMTC family composed of 30 members with 11 carriers. Cysteine ret proto-oncogene Homo sapiens
4 We report a RET mutation in exon10, codon 618 that causes substitution of a cysteine by a serine in the cysteine-rich domain of the RET receptor in a three-generation FMTC family composed of 30 members with 11 carriers. Cysteine ret proto-oncogene Homo sapiens
5 We report a RET mutation in exon10, codon 618 that causes substitution of a cysteine by a serine in the cysteine-rich domain of the RET receptor in a three-generation FMTC family composed of 30 members with 11 carriers. Cysteine ret proto-oncogene Homo sapiens
6 The FMTC with cysteine RET mutations found in the Korean population is consistent with the clinical pattern reported worldwide; to date there have been no ethnic differences identified for FMTC. Cysteine ret proto-oncogene Homo sapiens