Title : Phorbol ester-mediated inhibition of growth and regulation of proto-oncogene expression in the human T cell leukemia line JURKAT.

Pub. Date : 1991 Mar

PMID : 2011401






3 Functional Relationships(s)
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1 Treating JURKAT cells with the phorbol ester tetradecanoyl phorbol acetate (TPA) inhibited their proliferation and induced expression of the gene for the interleukin 2 receptor alpha chain (IL2R-alpha), consistent with previous reports. Tetradecanoylphorbol Acetate interleukin 2 receptor subunit alpha Homo sapiens
2 In contrast, accumulation of mRNAs for the C-FOS, C-JUN, and EGR-1 genes increased markedly in TPA-treated cells and preceded the induction of IL2R-alpha mRNA. Tetradecanoylphorbol Acetate interleukin 2 receptor subunit alpha Homo sapiens
3 Despite sustained expression of C-MYC, BCL2, or the combination of these protooncogenes, TPA continued to inhibit JURKAT cell growth and to induce IL2R expression. Tetradecanoylphorbol Acetate interleukin 2 receptor subunit alpha Homo sapiens