Pub. Date : 1991 Mar
PMID : 2011401
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treating JURKAT cells with the phorbol ester tetradecanoyl phorbol acetate (TPA) inhibited their proliferation and induced expression of the gene for the interleukin 2 receptor alpha chain (IL2R-alpha), consistent with previous reports. | Tetradecanoylphorbol Acetate | interleukin 2 receptor subunit alpha | Homo sapiens |
| 2 | In contrast, accumulation of mRNAs for the C-FOS, C-JUN, and EGR-1 genes increased markedly in TPA-treated cells and preceded the induction of IL2R-alpha mRNA. | Tetradecanoylphorbol Acetate | interleukin 2 receptor subunit alpha | Homo sapiens |
| 3 | Despite sustained expression of C-MYC, BCL2, or the combination of these protooncogenes, TPA continued to inhibit JURKAT cell growth and to induce IL2R expression. | Tetradecanoylphorbol Acetate | interleukin 2 receptor subunit alpha | Homo sapiens |