Pub. Date : 2010 Jan 29
PMID : 20113502
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine enhances murine airway contractile responses to kinin receptor agonists via activation of JNK- and PDE4-related intracellular pathways. | Nicotine | mitogen-activated protein kinase 8 | Mus musculus |
| 2 | Confocal-microscopy-based immunohistochemistry showed that 4 days of nicotine treatment induced activation (phosphorylation) of c-Jun N-terminal kinase (JNK), but not extracellular signal-regulated kinase 1 and 2 (ERK1/2) and p38. | Nicotine | mitogen-activated protein kinase 8 | Mus musculus |
| 3 | Confocal-microscopy-based immunohistochemistry showed that 4 days of nicotine treatment induced activation (phosphorylation) of c-Jun N-terminal kinase (JNK), but not extracellular signal-regulated kinase 1 and 2 (ERK1/2) and p38. | Nicotine | mitogen-activated protein kinase 8 | Mus musculus |
| 4 | Inhibition of JNK with its specific inhibitor SP600125 abolished the nicotine-induced effects on kinin receptor-mediated contractions and reverted the enhanced receptor mRNA expression. | Nicotine | mitogen-activated protein kinase 8 | Mus musculus |