Title : A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes.

Pub. Date : 2010

PMID : 20113495






3 Functional Relationships(s)
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1 METHODS: The human chondrosarcoma cell line HTB-94 and human primary chondrocytes were stimulated with tumor necrosis factor (TNF)alpha after pre-treatment with GlcN or NAPA. Glucosamine tumor necrosis factor Homo sapiens
2 METHODS: The human chondrosarcoma cell line HTB-94 and human primary chondrocytes were stimulated with tumor necrosis factor (TNF)alpha after pre-treatment with GlcN or NAPA. Glucosamine tumor necrosis factor Homo sapiens
3 RESULTS: After TNFalpha stimulation, the mRNA expression level of some of the genes under NF-kappaB control, such as interleukin (IL)-6 and IL-8, increased, while treatment with GlcN and NAPA reverted the effect. Glucosamine tumor necrosis factor Homo sapiens