Title : Nutrient modification of the innate immune response: a novel mechanism by which saturated fatty acids greatly amplify monocyte inflammation.

Pub. Date : 2010 Apr

PMID : 20110572






3 Functional Relationships(s)
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1 METHODS AND RESULTS: THP-1 monocytes exposed to 100 micromol/L SFA in vitro for 16 hours followed by 1 ng/mL lipopolysaccharide demonstrated enhanced IL-6 and IL-8 mRNA and protein expression (approximately 3-fold higher than the sum of individual responses to SFA and lipopolysaccharide). Fatty Acids GLI family zinc finger 2 Homo sapiens
2 METHODS AND RESULTS: THP-1 monocytes exposed to 100 micromol/L SFA in vitro for 16 hours followed by 1 ng/mL lipopolysaccharide demonstrated enhanced IL-6 and IL-8 mRNA and protein expression (approximately 3-fold higher than the sum of individual responses to SFA and lipopolysaccharide). Fatty Acids GLI family zinc finger 2 Homo sapiens
3 SFA had similar effects on THP-1 macrophages and primary human monocytes. Fatty Acids GLI family zinc finger 2 Homo sapiens