Title : COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems.

Pub. Date : 2010 Mar

PMID : 20110411






1 Functional Relationships(s)
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1 The present results address the novel activities of COX-2/PGE2-EP3/EP4 signaling that modulate tumor biology and show that CXCL12/CXCR4 axis may play a crucial role in tumor stromal formation and angiogenesis under the control of prostaglandins. Dinoprostone prostaglandin E receptor 4 (subtype EP4) Mus musculus