Pub. Date : 2010 Sep 6
PMID : 20109441
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We previously reported a free cysteine (Cys) residue at the entrance to the AChE active site in some insects but not higher vertebrates. | Cysteine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | We previously reported a free cysteine (Cys) residue at the entrance to the AChE active site in some insects but not higher vertebrates. | Cysteine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | We also reported Cys-targeting methanethiosulfonate molecules (AMTSn), which, under conditions that spared human AChE, caused total irreversible inhibition of aphid AChE, 95% inhibition of AChE from the malaria vector mosquito (Anopheles gambia), and >80% inhibition of activity from the yellow fever mosquito (Aedes aegypti) and northern house mosquito (Culex pipiens). | Cysteine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | We also reported Cys-targeting methanethiosulfonate molecules (AMTSn), which, under conditions that spared human AChE, caused total irreversible inhibition of aphid AChE, 95% inhibition of AChE from the malaria vector mosquito (Anopheles gambia), and >80% inhibition of activity from the yellow fever mosquito (Aedes aegypti) and northern house mosquito (Culex pipiens). | Cysteine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | We also reported Cys-targeting methanethiosulfonate molecules (AMTSn), which, under conditions that spared human AChE, caused total irreversible inhibition of aphid AChE, 95% inhibition of AChE from the malaria vector mosquito (Anopheles gambia), and >80% inhibition of activity from the yellow fever mosquito (Aedes aegypti) and northern house mosquito (Culex pipiens). | Cysteine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |