Title : cAMP-induced auditory supporting cell proliferation is mediated by ERK MAPK signaling pathway.

Pub. Date : 2010 Jun

PMID : 20107853






6 Functional Relationships(s)
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1 Here, we show that FSK-induced supporting cell proliferation is mediated by cell-specific accumulation of cyclic adenosine monophosphate (cAMP) in avian supporting cells and the extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) pathway. Colforsin mitogen-activated protein kinase 1 Homo sapiens
2 Here, we show that FSK-induced supporting cell proliferation is mediated by cell-specific accumulation of cyclic adenosine monophosphate (cAMP) in avian supporting cells and the extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) pathway. Colforsin mitogen-activated protein kinase 1 Homo sapiens
3 Here, we show that FSK-induced supporting cell proliferation is mediated by cell-specific accumulation of cyclic adenosine monophosphate (cAMP) in avian supporting cells and the extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) pathway. Colforsin mitogen-activated protein kinase 1 Homo sapiens
4 By a combination of immunostaining and pharmacological analyses, we show that FSK treatment increases cAMP levels in avian auditory supporting cells and that several ERK MAP inhibitors effectively block FSK-induced supporting cell proliferation. Colforsin mitogen-activated protein kinase 1 Homo sapiens
5 Collectively, these data suggest that FSK-induced supporting cell proliferation in the avian auditory epithelium is mediated by increases of cAMP levels in supporting cells and the cell-specific expression of the ERK MAPK family member B-Raf in supporting cells. Colforsin mitogen-activated protein kinase 1 Homo sapiens
6 Collectively, these data suggest that FSK-induced supporting cell proliferation in the avian auditory epithelium is mediated by increases of cAMP levels in supporting cells and the cell-specific expression of the ERK MAPK family member B-Raf in supporting cells. Colforsin mitogen-activated protein kinase 1 Homo sapiens