Title : Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway.

Pub. Date : 2010 Mar

PMID : 20107192






1 Functional Relationships(s)
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1 In hearts of untreated diabetic mice, the expression and activity of Akt/Pim-1 signaling declined along with O-N-acetylglucosamine modification of Akt, inhibition of pentose phosphate pathway, activation of oxidative stress, and accumulation of glycation end products. Pentosephosphates thymoma viral proto-oncogene 1 Mus musculus