Title : Tubuloglomerular feedback is decreased in COX-1 knockout mice after chronic angiotensin II infusion.

Pub. Date : 2010 Apr

PMID : 20107114






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Prostaglandins (PGs), produced by two isoforms of cyclooxygenase (COX), COX-1 and COX-2, are important modulators of renal hemodynamics. Prostaglandins cytochrome c oxidase I, mitochondrial Mus musculus
2 Prostaglandins (PGs), produced by two isoforms of cyclooxygenase (COX), COX-1 and COX-2, are important modulators of renal hemodynamics. Prostaglandins cytochrome c oxidase I, mitochondrial Mus musculus
3 Genetic deletion of COX-1 enhances COX-2 production of PGs, decreases renal and urinary PGs, and attenuates ANG II-induced hypertension. Prostaglandins cytochrome c oxidase I, mitochondrial Mus musculus
4 Genetic deletion of COX-1 enhances COX-2 production of PGs, decreases renal and urinary PGs, and attenuates ANG II-induced hypertension. Prostaglandins cytochrome c oxidase I, mitochondrial Mus musculus
5 This study shows that COX-1-generated PGs partially mediate ANG II increases in TGF and that COX-2 PGs offset that effect. Prostaglandins cytochrome c oxidase I, mitochondrial Mus musculus