Pub. Date : 2010 Jan 27
PMID : 20105315
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The mitochondria-independent cytotoxic effect of nelfinavir on leukemia cells can be enhanced by sorafenib-mediated mcl-1 downregulation and mitochondrial membrane destabilization. | Nelfinavir | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 2 | Despite caspase activation, the upregulation of the anti-apoptotic bcl-2 family member protein mcl-1 that resulted from nelfinavir treatment stabilized the mitochondrial membrane potential, resulting in primarily mitochondria-independent cell death. | Nelfinavir | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 3 | Pharmacological downregulation of mcl-1 expression by treatment with sorafenib (2 microg/ml) significantly enhanced nelfinavir-induced apoptosis even at lower nelfinavir concentrations (5 microg/ml), but did not have additional detrimental effects on non-malignant bone marrow cells. | Nelfinavir | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 4 | Pharmacological downregulation of mcl-1 expression by treatment with sorafenib (2 microg/ml) significantly enhanced nelfinavir-induced apoptosis even at lower nelfinavir concentrations (5 microg/ml), but did not have additional detrimental effects on non-malignant bone marrow cells. | Nelfinavir | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |