Title : ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy.

Pub. Date : 2010 Feb

PMID : 20104019






1 Functional Relationships(s)
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1 Three widely used ER stress inducers including tunicamycin, DTT and MG132 led to the conversion of LC3-I to LC3-II , a commonly used marker of autophagy, as well as the downregulation of mTOR concurrently. Tunicamycin mechanistic target of rapamycin kinase Homo sapiens