Pub. Date : 2010 Feb 1
PMID : 20103647
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. | Resveratrol | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Here, we report that the plant phytoalexin resveratrol (RSV) triggers autophagy in imatinib-sensitive and imatinib-resistant chronic myelogenous leukemia (CML) cells via JNK-dependent accumulation of p62. | Resveratrol | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Here, we report that the plant phytoalexin resveratrol (RSV) triggers autophagy in imatinib-sensitive and imatinib-resistant chronic myelogenous leukemia (CML) cells via JNK-dependent accumulation of p62. | Resveratrol | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | JNK inhibition or p62 knockdown prevented RSV-mediated autophagy and antileukemic effects. | Resveratrol | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | We concluded that RSV triggered autophagic cell death in CML cells via both JNK-mediated p62 overexpression and AMPK activation. | Resveratrol | mitogen-activated protein kinase 8 | Homo sapiens |