Title : Caffeine confers radiosensitization of PTEN-deficient malignant glioma cells by enhancing ionizing radiation-induced G1 arrest and negatively regulating Akt phosphorylation.

Pub. Date : 2010 Feb

PMID : 20103602






1 Functional Relationships(s)
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1 Our data suggest that the methylxanthine caffeine or its derivative pentoxifylline are promising candidate drugs for the radiosensitization of glioma cells particularly with PTEN mutations. methylxanthine phosphatase and tensin homolog Homo sapiens