Pub. Date : 2010 Jan 26
PMID : 20102612
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Retinoic acid protects human breast cancer cells against etoposide-induced apoptosis by NF-kappaB-dependent but cIAP2-independent mechanisms. | Etoposide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Supporting this crosstalk, the activation of NF-kappaB by retinoids in T47D cells antagonizes the apoptosis triggered by the chemotherapeutic drugs etoposide, camptothecin or doxorubicin. | Etoposide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | However, ectopic overexpression of a NF-kappaB repressor increases apoptosis by retinoids moderately and abrogates almost completely the retinoid-dependent inhibition of etoposide-induced apoptosis. | Etoposide | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Our data exclude cIAP2 and suggest that retinoids target other regulator(s) of the NF-kappaB signaling pathway to induce resistance to etoposide on certain breast cancer cells. | Etoposide | nuclear factor kappa B subunit 1 | Homo sapiens |