Title : AZD6244 (ARRY-142886) enhances the antitumor activity of rapamycin in mouse models of human hepatocellular carcinoma.

Pub. Date : 2010 Mar 1

PMID : 20101735






1 Functional Relationships(s)
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1 RESULTS: We report here that pharmacological inhibition of the MEK/ERK pathway by AZD6244 enhanced the antitumor and antiangiogenic activities of mTOR inhibitor RAPA in both orthotopic and ectopic models of HCC. AZD 6244 mitogen-activated protein kinase 1 Homo sapiens