Title : A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila.

Pub. Date : 2010 Apr

PMID : 20100940






3 Functional Relationships(s)
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1 We generated transgenic fly lines that express enhanced-GFP-tagged mutant Huntingtin (Htt) fragments with different lengths of polyglutamine (polyQ) tract and showed that these Htt mutants develop protein aggregates in a polyQ-length- and age-dependent manner in Drosophila. polyglutamine huntingtin Drosophila melanogaster
2 We generated transgenic fly lines that express enhanced-GFP-tagged mutant Huntingtin (Htt) fragments with different lengths of polyglutamine (polyQ) tract and showed that these Htt mutants develop protein aggregates in a polyQ-length- and age-dependent manner in Drosophila. polyglutamine huntingtin Drosophila melanogaster
3 We generated transgenic fly lines that express enhanced-GFP-tagged mutant Huntingtin (Htt) fragments with different lengths of polyglutamine (polyQ) tract and showed that these Htt mutants develop protein aggregates in a polyQ-length- and age-dependent manner in Drosophila. polyglutamine huntingtin Drosophila melanogaster