Title : Antioxidant activities of oleanolic acid in vitro: possible role of Nrf2 and MAP kinases.

Pub. Date : 2010 Mar 30

PMID : 20100471






2 Functional Relationships(s)
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1 OA ameliorated the oxidative injury induced by tBHP through increasing the generation of antioxidant (glutathione) and the expression of key antioxidant enzymes mediated by nuclear factorerythroid 2 p45-related factor 2 (Nrf2), in which process, activation of JNK and ERK, but not p38, was involved. tert-Butylhydroperoxide mitogen-activated protein kinase 1 Homo sapiens
2 OA probably functions mainly through indirect biological effect and protects QZG cells against cytotoxicity induced by tBHP through increasing the generation of antioxidant and the expression of oxidative stress sensitive transcription factor-Nrf2, and MAP kinases, mainly JNK and ERK. tert-Butylhydroperoxide mitogen-activated protein kinase 1 Homo sapiens