Pub. Date : 2010 Apr 1
PMID : 20096707
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To test the hypothesis that Parp1 is preferentially activated by methyl methanesulfonate (MMS) exposure of Pol beta KO MEFs, we have examined the relationship between Pol beta expression, Parp1 activation and cell survival following MMS exposure in a series of WT and Pol beta deficient MEF cell lines. | Methyl Methanesulfonate | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 2 | To test the hypothesis that Parp1 is preferentially activated by methyl methanesulfonate (MMS) exposure of Pol beta KO MEFs, we have examined the relationship between Pol beta expression, Parp1 activation and cell survival following MMS exposure in a series of WT and Pol beta deficient MEF cell lines. | Methyl Methanesulfonate | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 3 | Both the MMS-induced activation of Parp1 and the MMS-induced cytotoxicity of Pol beta KO MEFs are attenuated by pre-treatment with the Parp1/Parp2 inhibitor PJ34. | Methyl Methanesulfonate | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 4 | Both the MMS-induced activation of Parp1 and the MMS-induced cytotoxicity of Pol beta KO MEFs are attenuated by pre-treatment with the Parp1/Parp2 inhibitor PJ34. | Methyl Methanesulfonate | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 5 | Both the MMS-induced activation of Parp1 and the MMS-induced cytotoxicity of Pol beta KO MEFs are attenuated by pre-treatment with the Parp1/Parp2 inhibitor PJ34. | Methyl Methanesulfonate | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 6 | In addition, the MMS-induced cellular sensitivity of Pol beta KO MEFs is reversed when Parp1 is also deleted (Pol beta/Parp1 double KO MEFs) and we observe no MMS sensitivity differential between Pol beta/Parp1 double KO MEFs and those that express recombinant mouse Pol beta. | Methyl Methanesulfonate | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 7 | In addition, the MMS-induced cellular sensitivity of Pol beta KO MEFs is reversed when Parp1 is also deleted (Pol beta/Parp1 double KO MEFs) and we observe no MMS sensitivity differential between Pol beta/Parp1 double KO MEFs and those that express recombinant mouse Pol beta. | Methyl Methanesulfonate | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 8 | In addition, the MMS-induced cellular sensitivity of Pol beta KO MEFs is reversed when Parp1 is also deleted (Pol beta/Parp1 double KO MEFs) and we observe no MMS sensitivity differential between Pol beta/Parp1 double KO MEFs and those that express recombinant mouse Pol beta. | Methyl Methanesulfonate | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |