Pub. Date : 2010 Jan 22
PMID : 20096120
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cancer cell sensitivity to bortezomib is associated with survivin expression and p53 status but not cancer cell types. | Bortezomib | tumor protein p53 | Homo sapiens |
| 2 | RESULTS: We found that cancer cells with wild type p53 show a low level expression of survivin and are sensitive to treatment with bortezomib, while cancer cells with a mutant or null p53 show a high level expression of survivin and are resistant to bortezomib-mediated apoptosis induction. | Bortezomib | tumor protein p53 | Homo sapiens |
| 3 | RESULTS: We found that cancer cells with wild type p53 show a low level expression of survivin and are sensitive to treatment with bortezomib, while cancer cells with a mutant or null p53 show a high level expression of survivin and are resistant to bortezomib-mediated apoptosis induction. | Bortezomib | tumor protein p53 | Homo sapiens |
| 4 | We further noted that modulation of survivin expression by bortezomib is dependent on p53 status but independent of cancer cell types. | Bortezomib | tumor protein p53 | Homo sapiens |
| 5 | CONCLUSIONS: Our findings, for the first time, unify the current inconsistent findings for bortezomib treatment and survivin expression, and linked the effect of bortezomib on survivin expression, apoptosis induction and bortezomib resistance in the relationship with p53 status, which is independent of cancer cell types. | Bortezomib | tumor protein p53 | Homo sapiens |
| 6 | CONCLUSIONS: Our findings, for the first time, unify the current inconsistent findings for bortezomib treatment and survivin expression, and linked the effect of bortezomib on survivin expression, apoptosis induction and bortezomib resistance in the relationship with p53 status, which is independent of cancer cell types. | Bortezomib | tumor protein p53 | Homo sapiens |