Title : Expression of HSP27, HSP72 and MRP proteins in in vitro co-culture of colon tumour cell spheroids with normal cells after incubation with rhTGF- beta1 and/or CPT-11.

Pub. Date : 2009 Dec

PMID : 20093746






1 Functional Relationships(s)
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1 rhTGF-beta1 and/or CPT-11 may potentate resistance to chemotherapy by increasing HSP and MRP expression but, on the other hand, they may limit tumour cell spread by decreasing the level of some soluble mediators of inflammation (IL-6 and NO). Irinotecan ATP binding cassette subfamily C member 1 Homo sapiens