Pub. Date : 2010 Mar 26
PMID : 20093358
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Additional investigations of other NF-kappaB inhibitors revealed that the synthetic I kappaB kinase-beta inhibitor Bay 11-7082 and structurally related vinyl sulfone compounds selectively inhibit NLRP3 inflammasome activity in macrophages independent of their inhibitory effect on NF-kappaB activity. | 3-(4-methylphenylsulfonyl)-2-propenenitrile | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | In vitro assays of the effect of parthenolide and Bay 11-7082 on the ATPase activity of NLRP3 demonstrated that both compounds inhibit the ATPase activity of NLRP3, suggesting that the inhibitory effect of these compounds on inflammasome activity could be mediated in part through their effect on the ATPase activity of NLRP3. | 3-(4-methylphenylsulfonyl)-2-propenenitrile | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | In vitro assays of the effect of parthenolide and Bay 11-7082 on the ATPase activity of NLRP3 demonstrated that both compounds inhibit the ATPase activity of NLRP3, suggesting that the inhibitory effect of these compounds on inflammasome activity could be mediated in part through their effect on the ATPase activity of NLRP3. | 3-(4-methylphenylsulfonyl)-2-propenenitrile | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | In vitro assays of the effect of parthenolide and Bay 11-7082 on the ATPase activity of NLRP3 demonstrated that both compounds inhibit the ATPase activity of NLRP3, suggesting that the inhibitory effect of these compounds on inflammasome activity could be mediated in part through their effect on the ATPase activity of NLRP3. | 3-(4-methylphenylsulfonyl)-2-propenenitrile | NLR family pyrin domain containing 3 | Homo sapiens |