Pub. Date : 2010 Mar
PMID : 20088784
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gefitinib targets EGFR dimerization and ERK1/2 phosphorylation to inhibit pleural mesothelioma cell proliferation. | Gefitinib | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | Gefitinib inhibited both EGFR and ERK1/2 activation, being maximal at drug concentrations that induce cytostatic effects, suggesting that the proapoptotic activity of Gefitinib is independent from EGFR inhibition. | Gefitinib | mitogen-activated protein kinase 3 | Homo sapiens |