Title : Control of Alzheimer's amyloid beta toxicity by the high molecular weight immunophilin FKBP52 and copper homeostasis in Drosophila.

Pub. Date : 2010 Jan 13

PMID : 20084280






3 Functional Relationships(s)
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1 Interestingly, the Abeta pathology was enhanced by mutations in the copper transporters Atox1, which interacts with FKBP52, and Ctr1A and was suppressed in FKBP52 mutant flies raised on a copper chelator diet. Copper FKBP prolyl isomerase 4 Homo sapiens
2 Interestingly, the Abeta pathology was enhanced by mutations in the copper transporters Atox1, which interacts with FKBP52, and Ctr1A and was suppressed in FKBP52 mutant flies raised on a copper chelator diet. Copper FKBP prolyl isomerase 4 Homo sapiens
3 Using mammalian cultures, we show that FKBP52 (-/-) cells have increased intracellular copper and higher levels of Abeta. Copper FKBP prolyl isomerase 4 Homo sapiens