Title : The orphan nuclear receptor NR4A1 regulates transcription of key steroidogenic enzymes in ovarian theca cells.

Pub. Date : 2010 May 5

PMID : 20083153






2 Functional Relationships(s)
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1 Our results show that overexpression of NR4A1 in theca cells stimulates the expression of StAR, CYP11A1, CYP17 and HSD3B2, leading to increased testosterone production. Testosterone nuclear receptor subfamily 4, group A, member 1 Mus musculus
2 Conversely, knockdown of the endogenous NR4A1 exhibits a significant decrease in StAR, CYP11A1, CYP17 and HSD3B2 expression and testosterone production. Testosterone nuclear receptor subfamily 4, group A, member 1 Mus musculus