Title : Involvement of transducer of regulated cAMP response element-binding protein activity on corticotropin releasing hormone transcription.

Pub. Date : 2010 Mar

PMID : 20080871






3 Functional Relationships(s)
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1 In reporter gene assays, cotransfection of TORC1 or TORC2 potentiated the stimulatory effect of forskolin on CRH promoter activity but had no effect in cells treated with PMA. Colforsin corticotropin releasing hormone Homo sapiens
2 Knockout of endogenous TORC using silencing RNA markedly inhibited forskolin-activated CRH promoter activity in 4B cells, as well as the induction of endogenous CRH primary transcript by forskolin in primary neuronal cultures. Colforsin corticotropin releasing hormone Homo sapiens
3 Knockout of endogenous TORC using silencing RNA markedly inhibited forskolin-activated CRH promoter activity in 4B cells, as well as the induction of endogenous CRH primary transcript by forskolin in primary neuronal cultures. Colforsin corticotropin releasing hormone Homo sapiens