Title : N-Acetamideindolecarboxylic acid allosteric 'finger-loop' inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies.

Pub. Date : 2010 Feb 1

PMID : 20074949






1 Functional Relationships(s)
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1 SAR studies at the N(1)-position of allosteric indole-based HCV NS5B inhibitors has led to the discovery of acetamide derivatives with good cellular potency in subgenomic replicons (EC(50) <200 nM). indole sarcosine dehydrogenase Homo sapiens