Pub. Date : 2010 Apr 15
PMID : 20074581
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Blockage of JNK pathway enhances arsenic trioxide-induced apoptosis in human keratinocytes. | Arsenic Trioxide | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Our previous study found that arsenic trioxide (ATO)-induced activation of p21(WAF1/CIP1) (p21) led to A431 cell death through the antagonistic effects of the signaling of ERK1/2 and JNK1. | Arsenic Trioxide | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Our previous study found that arsenic trioxide (ATO)-induced activation of p21(WAF1/CIP1) (p21) led to A431 cell death through the antagonistic effects of the signaling of ERK1/2 and JNK1. | Arsenic Trioxide | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | In the current study, the inhibitory effects of JNK1 on ATO-induced p21 expression were explored. | Arsenic Trioxide | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | Finally, treatment with JNK inhibitor SP600125 could enhance ATO-induced apoptosis of HaCaT keratinocytes by using flow cytometry. | Arsenic Trioxide | mitogen-activated protein kinase 8 | Homo sapiens |