Title : Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage.

Pub. Date : 2010 Apr 2

PMID : 20074562






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 These results suggest that inhibition of COX-1, despite causing intestinal hypermotility, bacterial invasion and iNOS expression, up-regulates the expression of COX-2, and the PGE(2) derived from COX-2 counteracts the deleterious events caused by COX-1 inhibition and maintains mucosal integrity. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens