Title : Characterization of monoamine oxidases in mesenchymal stem cells: role in hydrogen peroxide generation and serotonin-dependent apoptosis.

Pub. Date : 2010 Oct

PMID : 20073575






6 Functional Relationships(s)
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1 We have recently shown that the serotonin-degrading enzyme monoamine oxidase A (MAO-A) generates large amount of hydrogen peroxide (H2O2) responsible for cell apoptosis. Hydrogen Peroxide monoamine oxidase A Homo sapiens
2 We have recently shown that the serotonin-degrading enzyme monoamine oxidase A (MAO-A) generates large amount of hydrogen peroxide (H2O2) responsible for cell apoptosis. Hydrogen Peroxide monoamine oxidase A Homo sapiens
3 We have recently shown that the serotonin-degrading enzyme monoamine oxidase A (MAO-A) generates large amount of hydrogen peroxide (H2O2) responsible for cell apoptosis. Hydrogen Peroxide monoamine oxidase A Homo sapiens
4 We have recently shown that the serotonin-degrading enzyme monoamine oxidase A (MAO-A) generates large amount of hydrogen peroxide (H2O2) responsible for cell apoptosis. Hydrogen Peroxide monoamine oxidase A Homo sapiens
5 Hydrogen peroxide generation requires 5-HT internalization into the cell and its degradation by MAO-A. Hydrogen Peroxide monoamine oxidase A Homo sapiens
6 In conclusion, these results show for the first time that the 5-HT-degrading enzyme MAO-A is an important source of H2O2 in MSCs and plays a major role in 5-HT-dependent MSCs apoptosis. Hydrogen Peroxide monoamine oxidase A Homo sapiens