Title : The role of the striatum in compulsive behavior in intact and orbitofrontal-cortex-lesioned rats: possible involvement of the serotonergic system.

Pub. Date : 2010 Mar

PMID : 20072118






1 Functional Relationships(s)
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1 We have recently found that lesions to the rat orbitofrontal cortex (OFC) led to an increase in compulsive lever-pressing that was prevented by systemic administration of the selective serotonin reuptake inhibitor paroxetine, and paralleled by an increase in the density of the striatal serotonin transporter. Paroxetine solute carrier family 6 member 4 Rattus norvegicus