Title : Lack of hemodynamic effects after extended heme synthesis inhibition by succinylacetone in rats.

Pub. Date : 2010 Apr

PMID : 20071481






2 Functional Relationships(s)
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1 Because NOS and sGC are important regulators of cardiovascular function, we hypothesized that inhibition of heme supply to these enzymes by SA would result in the induction of a measurable hypertensive response. succinylacetone guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus
2 After SA treatment, systemic nitrite/nitrate excretion was reduced by 72% (P < 0.001), and renal NOS and sGC activities were decreased by 32 (P < 0.05) and 38% (P < 0.01), respectively. succinylacetone guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus