Title : In vitro inhibition of aggrecanase activity by tetracyclines and proteoglycan loss from osteoarthritic human articular cartilage.

Pub. Date : 2010 Jun

PMID : 20069635






1 Functional Relationships(s)
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1 In vitro activity of aggrecanase-1 and -2 was recorded in the presence of 1-100 microM tetracycline, minocycline, or doxycyline. Tetracycline ADAM metallopeptidase with thrombospondin type 1 motif 4 Homo sapiens