Title : Evaluation of the predictive value of topoisomerase II alpha in patients with breast carcinoma.

Pub. Date : 2009

PMID : 20069504






2 Functional Relationships(s)
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1 The employed adjuvant therapy according to anthracycline therapeutic protocols was markedly more effective in TOP2A-positive patients as compared to the remaining individuals. Anthracyclines DNA topoisomerase II alpha Homo sapiens
2 The study demonstrated that in adjuvant therapy employed in infiltrating ductal carcinoma of the breast, not only HER2 but also TOP2A determination in cancer cells was of importance; for this reason, routine determinations by immunohistochemistry should be performed, especially when anthracycline treatment is planned. Anthracyclines DNA topoisomerase II alpha Homo sapiens