Title : High glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous IL-1beta and suppressor of cytokine signalling-1 in mouse pancreatic beta cells.

Pub. Date : 2010 May

PMID : 20067833






5 Functional Relationships(s)
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1 High glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous IL-1beta and suppressor of cytokine signalling-1 in mouse pancreatic beta cells. Glucose interleukin 1 beta Mus musculus
2 The aim of this study was to investigate whether high glucose can influence endogenous interleukin-1beta (IL-1beta) and SOCS expression thus affecting insulin signalling and survival in insulin-producing mouse pancreatic beta cells (betaTC-6). Glucose interleukin 1 beta Mus musculus
3 The aim of this study was to investigate whether high glucose can influence endogenous interleukin-1beta (IL-1beta) and SOCS expression thus affecting insulin signalling and survival in insulin-producing mouse pancreatic beta cells (betaTC-6). Glucose interleukin 1 beta Mus musculus
4 Glucose-induced attenuation of IRS-2/Akt-mediated signalling was associated with increased IL-1beta expression. Glucose interleukin 1 beta Mus musculus
5 These results indicated that glucose-induced endogenous IL-1beta expression increased betaTC-6 cells apoptosis by inhibiting, at least in part, IRS-2/Akt-mediated signalling through SOCS-1 upregulation. Glucose interleukin 1 beta Mus musculus