Pub. Date : 2010 May
PMID : 20067833
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | High glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous IL-1beta and suppressor of cytokine signalling-1 in mouse pancreatic beta cells. | Glucose | interleukin 1 beta | Mus musculus |
| 2 | The aim of this study was to investigate whether high glucose can influence endogenous interleukin-1beta (IL-1beta) and SOCS expression thus affecting insulin signalling and survival in insulin-producing mouse pancreatic beta cells (betaTC-6). | Glucose | interleukin 1 beta | Mus musculus |
| 3 | The aim of this study was to investigate whether high glucose can influence endogenous interleukin-1beta (IL-1beta) and SOCS expression thus affecting insulin signalling and survival in insulin-producing mouse pancreatic beta cells (betaTC-6). | Glucose | interleukin 1 beta | Mus musculus |
| 4 | Glucose-induced attenuation of IRS-2/Akt-mediated signalling was associated with increased IL-1beta expression. | Glucose | interleukin 1 beta | Mus musculus |
| 5 | These results indicated that glucose-induced endogenous IL-1beta expression increased betaTC-6 cells apoptosis by inhibiting, at least in part, IRS-2/Akt-mediated signalling through SOCS-1 upregulation. | Glucose | interleukin 1 beta | Mus musculus |