Title : Augmentation of 3-methylcholanthrene-induced bioactivation in the human hepatoma cell line HepG2 by the calcium channel blocker nicardipine.

Pub. Date : 2010 Mar

PMID : 20067464






2 Functional Relationships(s)
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1 The results from real time RT-PCR analysis demonstrated that Nic could induce CYP1 mRNAs and enhance the MC-mediated induction of the CYP1 mRNAs. Methylcholanthrene cytochrome P450 family 1 subfamily A member 1 Homo sapiens
2 The present findings demonstrate that Nic can enhance the MC-mediated induction of CYP1s, especially CYP1A1, and the formation of MC-DNA adduct in HepG2 cells. Methylcholanthrene cytochrome P450 family 1 subfamily A member 1 Homo sapiens