Pub. Date : 2009 Dec 24
PMID : 20064390
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The N-terminal 17 amino acids of huntingtin (NT17) can be phosphorylated on serines 13 and 16; however, the significance of these modifications in Huntington"s disease pathogenesis remains unknown. | Serine | huntingtin | Mus musculus |
| 2 | In this study, we developed BAC transgenic mice expressing full-length mutant huntingtin (fl-mhtt) with serines 13 and 16 mutated to either aspartate (phosphomimetic or SD) or alanine (phosphoresistant or SA). | Serine | huntingtin | Mus musculus |
| 3 | Moreover, modification of these serines in expanded repeat huntingtin peptides modulates aggregation and amyloid fibril formation in vitro. | Serine | huntingtin | Mus musculus |